Three people have died in a horrific collision in Victoria’s Macedon Ranges.

Two cars crashed on Bolinda-Darraweit Rd in Bolinda, east of Gisborne, about 7.20am Sunday.

Three out of the four occupants inside one of the cars died at the scene.

Know the news with the 7NEWS app: Download today

They have not yet been formally identified.

The fourth person inside the car was taken to hospital with life-threatening injuries.

The driver of the second vehicle involved was taken to hospital with non-life-threatening injuries.

“The exact circumstances surrounding the collision are yet to be determined and investigations remain ongoing,” police said.

Anyone who witnessed the incident, has dashcam footage or any other information is urged to contact Crime Stoppers.