WARNING: Distressing content.

A horror head-on crash has left one woman dead and another seriously injured north of Adelaide, with the frantic final moments before impact caught on camera.

Footage showed a white SUV travelling on the wrong side of the Sturt Highway at Daveyston, in the Barossa Valley, towards oncoming traffic around 8.25am on Tuesday.

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The driver of the car died at the scene.

Incredibly, a 32-year-old woman behind the wheel of a blue Toyota involved in the crash survived.

She was airlifted to Royal Adelaide Hospital with serious injuries.

Footage shows the horror moment of the crash. Credit: 7NEWS

A woman died and another was seriously injured. Credit: 7NEWS

Another driver told 7NEWS of her close call a short time earlier at Nuriootpa, at least 10km from where the crash happened.

“I was in the right lane, they were in the right lane just in the wrong direction,” witness Julia Dorrestyn said.

She was forced to swerve to avoid a collision.

“I had a last minute panic, I beeped the horn and then I had to hit the brakes and pull in behind a truck beside me to get out of the way,” she said.

“Terrifying, just confusion.”

Major crash investigators closed the highway for most of the day.

Police closed the highway for most of the day. Credit: 7NEWS

Witnesses reported stopping at the devastating scene to help before paramedics arrived.

“We had people that had run in to go help and try and help pull people that injured themselves,” Dorrestyn said.

“Shocking and disbelief that that’s occurred,” another witness said.

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